Ertapenem is used alone or in combination with other antibiotics to treat infections caused by bacteria in many different parts of the body. Ertapenem invanz is a carbapenem and betalactam antibiotic that interferes with bacterial cell wall synthesis in susceptible pathogens. Reserve use whenever possible, as it is one of our lastline antibiotics. The reconstituted solutions should be inspected visually for particulate matter and discolouration prior to administration, whenever the container permits. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Reconstitute 1 g with 10 ml water for injections or sodium chloride 0. These drugs have a broad spectrum of activity so are held in reserve for severe infections.
Do not selfinject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, syringes, iv tubing, and other items used to. Indications and dosages communityacquired pneumonia. The essential information you need to safely administer more than 400 intravenous drugs. Invanz ertapenem dosing, indications, interactions, adverse. Ertapenem injection invanz side effects, medical uses. It showed clinical activity in the treatment of obstetric and gynecological infections, skin and soft tissue infections, communityacquired pneumonia, urinary tract infections, and in. Previous studies of ertapenem stability have evaluated concentrations of 10 and 20 mgml following reconstitution and dilution in various iv infusion solutions and storage in various types of container.
Invanz ertapenem dosing, indications, interactions, adverse effects. The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. To reduce the development of drugresistant bacteria and maintain the effectiveness of invanz and other antibacterial drugs, invanz should. It works by killing bacteria or preventing their growth. Ertapenem is administered via intravenous iv or intramuscular im routes. A handbook for nurses and health professionals has been a trusted resource for comprehensive drug coverage, unparalleled accuracy, and an intuitive quickaccess format. It exhibits nonlinear pharmacokinetics due to a high level of concentrationdependent plasma protein binding to albumin. Sometimes they are serious, most of the time they are not. Antibiotic drugs, information, description on ertapenem. Ertapenem is a carbapenem antibiotic marketed by merck as invanz. Heparin drip compatibilty patient medications allnurses. The dose of invanz in patients years of age and older is 1 gram g given once a day. By inhibiting cell wall synthesis, ertapenem has a bactericidal action.
The most common ertapenem related aes in previous studies were elevated hepatic transaminase levels 8. Listing a study does not mean it has been evaluated by the u. Switching to iv push, using solutions other than saline, using large volume solutions, or using syringe infusion pumps, may change the stability and compatibility characteristics of the medication to be. Nov 15, 2019 compatibility of invanz with intravenous solutions containing heparin sodium and potassium chloride has been demonstrated. It will not work for colds, flu, or other viral infections. Ertapenem sodium dosage and administration administration. Ertapenem definition of ertapenem by medical dictionary. Each monograph contains stability data, administration guidelines, and methods of preparation. Ertapenem is a 1beta methylcarbapenem which is chemically similar to beta lactams. Prophylactic administration of ertapenem as a single 1g iv dose has been. Nov 09, 2018 ertapenem is an antibiotic that fights bacteria. Ertapenem is injected into a muscle or into a vein through an iv.
Therefore this book should be used as guidance only. This medication is given by injection into a muscle or vein, usually once. Invanz ertapenem for injection for intravenous iv or intramuscular im use. Provides a summary of interactions with vitamins, herbs, and food. Substitutes and alternatives to invanz ertapenem for uses like colorectal surgical site infection prophylaxis, community acquired pneumonia and diabetic foot infection without osteomyelitis.
Common and rare side effects for ertapenem intravenous. Intravenous iv preparation and infusion guidelines globalrph. Indications, dose, contraindications, sideeffects, interactions, cautions, warnings and other safety information for ertapenem. Jun 22, 2010 pharmacokinetics pk of ertapenem intravenous iv bolus versus standard infusion the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Aucs of total ertapenem and of unbound ertapenem are increased in patients with severe renal impairment cl cr 5 to 30 mlmin1. Ertapenem was reconstituted with sterile water for injection and then diluted with various commercial i. Stability and compatibility of reconstituted ertapenem with. Its molecular formula is c22h24n3o7sna and mw is 497. Stability of ertapenem 100 mgml in manufacturers glass vials or. This reference contains standard dilutions including iv admixture drug concentration, infusion volumes, and infusion rates. Trissel, fashp, 2010, american society of healthsystem pharmacists. Listing a study does not mean it has been evaluated by. The king guide to parenteral admixtures is designed to help practitioners decide which alternative administration strategy is best. The carbapenem ertapenem is one of several firstline agents recommended by the infectious disease society of america for the empiric treatment of communityacquired intraabdominal infections of mildtomoderate severity.
Ertapenem is a 1betamethyl carbapenem and broadspectrum betalactam antibiotic with bactericidal property. Solutions of invanz range from colourless to pale yellow. Agents with antipseudomonal activity, including doripenem, imipenem, and meropenem are not recommended in this population. Ertapenem solution, reconstituted recon soln side effects by likelihood and severity common side effects if experienced, these tend to have a severe expression. Dailymed invanz ertapenem sodium injection, powder. Invanz ertapenemfor injection for intravenous iv or intramuscular im use initial u. In this study, we aimed to evaluate the clinical efficacy and safety of ertapenem therapy in children with complicated utis caused by esblproducing. Ertapenem is used to prevent and treat a wide variety of bacterial infections. It is used to treat certain kinds of bacterial infections.
When i looked its compatibility with heparin up it said it was compatible at the ysite. The stability of ertapenem sodium in various commonly used i. Aucs of total ertapenem and of unbound ertapenem are increased in patients who require haemodialysis approximately 2. Ertapenem is used to treat a wide variety of bacterial infections. Patients over 75 receiving ertapenem for 48 hours iv or sc will be included. Invanz 1g powder for concentrate for solution for infusion. This medication is given by injection into a muscle or vein, usually once daily or as directed by your doctor. Invanz ertapenem dose, indications, adverse effects. Surgical intervention is the primary therapeutic intervention. I ran the abx on its own pump and connected it to the ysite on the heparin line. It is infused injected slowly intravenously over a period of at least 30 minutes once or twice a day for up to 14 days.
Antiinfective pregnancy risk category b action inhibits cellwall synthesis in bacteria, causing cell death availability powder for infusion lyophilized. Administration of ertapenem 1 gram iv push over 5 minutes was. Information about drug ertapenem includes cost of the drug and the type of drug tablet, capsule, syrup, cream, gel, ointment, liquid or injection. Ertapenem medicare coverage and copay details goodrx. Feb, 2020 the first trial enrolled 404 patients and compared ertapenem 15 mgkg intravenous iv every 12 hours in patients 3 months to 12 years of age, and 1 g iv once a day in patients to 17 years of age to ceftriaxone 50 mgkgday iv in two divided doses in patients 3 months to 12 years of age and 50 mgkgday iv as a single daily dose in. The king guide wall charts are a useful reference to have visible in the hospital and pharmacy for situations where a quick yes or no answer is needed. Stability and compatibility of reconstituted ertapenem. Side effects of invanz ertapenem injection, warnings, uses. Im sure there are plenty of reasons, but my choice would be that heparin needs to be a dedicated line so that people understand that its a critical drug that can cause death if not administered properly. This drug is for the specified moderate to severe infections due to susceptible isolates of the designated microorganisms. Urinary tract infections utis are common and important clinical problem in childhood, and extendedspectrumbetalactamase esbl producing organisms are the leading cause of healthcarerelated utis. Intravenous admixtures preparation and infusion guidelines. Following a single 1 g iv dose of ertapenem, the unbound auc increased 1.
In vitro it is active against anaerobes, gram positive and gram negative aerobic bacteria. So today pt pt was ordered a heparin drip and iv abx. Ertapenem plasma levels were drawn and were noted to be 79. Ertapenem injection comes as a powder to be mixed with liquid to be injected intravenously into a vein or intramuscularly into a muscle. Agents with antipseudomonal activity, including doripenem, imipenem, and meropenem are not recommended. Invanz, invanz addvantage ertapenem uses, side effects. Stability of ertapenem 100 mgml in manufacturers glass.
This medicine will not work for colds, flu, or other virus infections. Ertapenem injection route description and brand names mayo. This medication is known as a carbapenemtype antibiotic. For solution and drug compatibility information, see compatibility under stability. The first trial enrolled 404 patients and compared ertapenem 15 mgkg intravenous iv every 12 hours in patients 3 months to 12 years of age, and 1 g iv once a day in patients to 17 years of age to ceftriaxone 50 mgkgday iv in two divided doses in patients 3 months to 12 years of age and 50 mgkgday iv as a single daily dose in. Ertapenem is used to treat severe infections of the skin, lungs, stomach, pelvis, and urinary tract. Check out these bestsellers and special offers on books and. It is also may be given once or twice a day intramuscularly for up to 7 days. Guidelines recommend ertapenem for mixed necrotizing infections. Pharmacokinetics of ertapenem in patients aged over 75.
Pharmacokinetics pk of ertapenem intravenous iv bolus. Ertapenem is a bacterial cell wall biosynthesis inhibitor with activity against a wide range of gramnegative and grampositive bacteria and resistance to a broad and extended spectrum of. Complicated urinary tract infections including pyelonephritis iv im q12hr up to 14 days. Total and unbound fractions of ertapenem pharmacokinetics were investigated in 26 adult subjects 31 to 80 years of age with varying degrees of renal impairment. Ertapenem binds to penicillin binding proteins pbps located on the bacterial cell wall, in particular pbps 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Stability and compatibility of reconstituted ertapenem with commonly used i. Invanz helps most people with infection, but it may have unwanted sideeffects in a few people. Systemic and local adverse effects will be collected during the treatment and infection evolution will be described. Home explore intravenous compatibility chart drug information for the. Ertapenem injection route description and brand names. Pharmacokinetics pk of ertapenem intravenous iv bolus versus standard infusion the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4. One abx was vanco which is not compatible with heparin the other abx was azactam sp.
Ertapenem sodium is a synthetically derived, parenteral carbapenem antibiotic. Intravenous compatibility chart drug information for the. In addition, new compatibility information is reported for these existing monographs. Ertapenem is used alone or in combination with other antibiotics to treat. Invanz ertapenem dosing, indications, interactions. Jan 24, 2020 1 g iv or im once a day for 3 to 10 days. For the treatment of acute pelvic infections including postpartum endomyometritis, septic abortion, postsurgical gynecological infections due to streptococcus agalactiae, e coli, b fragilis, porphyromonas asaccharolytica, peptostreptococcus species, or prevotella bivia. Do not selfinject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, syringes, iv tubing, and other items used to inject the medicine. The clinical efficacy and safety of ertapenem for the. Stability and compatibility of reconstituted ertapenem with commonly. In addition to updating drug interactions, precautions, alerts, and patient teaching. Morphine sulfate, ropivacaine hydrochloride, and ziconotide. With 122 iv drugs and 4 fluids the wall charts provide a comprehensive view of ysite compatibility for critical care admixtures and chemotherapy admixtures on a 27 x 27 wall chart.